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Effects of some adenosine analogs on morphine-induced analgesia and tolerance
E Contreras1, A Germany, M Villar
1Departamento de Ciencias Fisiológicas, Facultad de Ciencias Biológicas y de Recursos Naturales, Universidad de Concepción, Chile.
General Pharmacology
|January 1, 1990
Abstract:
1. The analogs of adenosine D- and L-phenylisopropyladenosine (D- and L-PIA) and chloroadenosine (CADO) induced analgesia in mice (hot-plate test). 2. The antinociceptive effects of the three adenosine agonists were antagonized by caffeine but were unaffected by naloxone. 3. Morphine-induced antinociception was increased by pretreatment with adenosine agonists. 4. Whereas CADO significantly attenuated the induction of morphine tolerance, D- and L-PIA did not affect the process.