Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Disorders of Hemostasis

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.

Fetal Circulation

Fetal Circulation

Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...

Development of Blood Vessels

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...

Hemorrhagic Stroke l: Introduction

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

Hemorrhagic Stroke ll: Pathophysiology

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

Mitral Valve Prolapse III: Nursing Management

Mitral Valve Prolapse III: Nursing Management

The nursing management of Mitral Valve Prolapse, or MVP, centers around patient education, symptom monitoring, and lifestyle modifications.Patient Education on MVP Diagnosis and Heredity: Nurses should provide comprehensive education about MVP, a condition where the mitral valve does not close appropriately during heartbeats. This education often includes the condition's pathophysiology, symptoms, and potential complications, like arrhythmias or mitral regurgitation. Though not fully...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Third-Trimester Cardiovascular Function and Risk of Hypertensive Disorders of Pregnancy.

Journal of the American Heart Association·2024

Same author

Development and validation of a prognostic model to predict birth weight: individual participant data meta-analysis.

BMJ medicine·2024

Same author

Reference ranges for third-trimester maternal cardiovascular function parameters measured in normotensive pregnant women using a non-invasive cardiac output monitor: A study based on data from the prospective PEACH cohort study.

BJOG : an international journal of obstetrics and gynaecology·2023

Same author

Author reply.

BJOG : an international journal of obstetrics and gynaecology·2023

Same author

Incidence and outcomes of uterine rupture in women with unscarred, preterm or prelabour uteri: data from the international network of obstetric survey systems.

BJOG : an international journal of obstetrics and gynaecology·2023

Same author

Wexner score and quality of life in women with obstetric anal sphincter injury.

International urogynecology journal·2019

Search research articles

Related Experiment Video

Updated: May 20, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

First trimester bleeding and maternal cardiovascular morbidity.

Jacob A Lykke¹, Jens Langhoff-Roos

¹Department of Obstetrics and Gynecology, Roskilde Hospital, Roskilde, Denmark. dr.lykke@dadlnet.dk

European Journal of Obstetrics, Gynecology, and Reproductive Biology

|July 7, 2012

Summary

First trimester bleeding without miscarriage is linked to pre-pregnancy cardiovascular disease and increases the risk of later maternal ischemic heart disease. This study highlights cardiovascular risks associated with early pregnancy bleeding.

More Related Videos

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Published on: May 5, 2018

Related Experiment Videos

Last Updated: May 20, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

Published on: January 26, 2024

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound (30/45MHZ) System

Published on: May 5, 2018

Area of Science:

Obstetrics and Gynecology
Cardiology
Epidemiology

Background:

First trimester bleeding without miscarriage is a known risk factor for adverse pregnancy outcomes like preterm delivery.
Previous research suggests a link between first trimester miscarriage and subsequent maternal ischemic heart disease.
The association between first trimester bleeding without miscarriage and maternal cardiovascular disease (CVD) requires further investigation.

Purpose of the Study:

To investigate the relationship between maternal cardiovascular disease (CVD) before and after first trimester bleeding without miscarriage.
To assess the impact of pre-pregnancy CVD on the occurrence of first trimester bleeding without miscarriage.
To determine if first trimester bleeding without miscarriage is associated with an increased risk of subsequent maternal CVD.

Main Methods:

A retrospective cohort study utilizing Danish national registry data from 1978-2007, including 796,915 women.
Exposures included pre-pregnancy cardiovascular disease, first trimester vaginal bleeding without miscarriage, and subsequent maternal cardiovascular disease.
Logistic regression and Cox proportional hazard models were used, adjusting for potential confounders such as preterm delivery and hypertensive disorders.

Main Results:

Women with pre-pregnancy cardiovascular disease had a 2.2-fold increased risk of first trimester bleeding without miscarriage.
First trimester bleeding without miscarriage was associated with a 1.6-fold increased risk of subsequent maternal ischemic heart disease, even after adjusting for other adverse pregnancy outcomes.

Conclusions:

First trimester bleeding without miscarriage is significantly associated with pre-existing maternal cardiovascular disease.
This early pregnancy complication is also linked to an elevated risk of developing cardiovascular morbidity later in life.