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Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring
Published on: August 17, 2022
Altered immune function in unaffected first-degree biological relatives of schizophrenia patients
Isabel Martínez-Gras1, Fernando García-Sánchez, Carmen Guaza
1Department of Psychiatry, Faculty of Medicine, Complutense University, Madrid, Spain. isabelmgras@gmail.com
Abstract:
Inflammatory and immune processes have been implicated in the etiopathology of schizophrenia. We demonstrate the existence of immune function alteration, assessed by serum cytokine's levels, not only in schizophrenia patients but also in their unaffected first-degree relatives. This finding may provide a new data for considering cytokines as schizophrenic disease biomarkers.
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