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Stimulation region within the globus pallidus does not affect verbal fluency performance.

Jenna Dietz1, Angela M Noecker, Cameron C McIntyre

  • 1Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.

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|July 7, 2012
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Summary

Deep brain stimulation (DBS) of the globus pallidus (GP) in Parkinson

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Area of Science:

  • Neuroscience
  • Neurosurgery
  • Neurology

Background:

  • Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus (GP) effectively treats Parkinson's disease motor symptoms.
  • STN DBS is associated with more cognitive and mood side effects than GP DBS, necessitating further research into target-specific differences.
  • Previous research indicated that stimulation location within the STN impacts verbal fluency.

Purpose of the Study:

  • To investigate the relationship between stimulation location, volume of tissue activated, and verbal fluency in Parkinson's patients undergoing globus pallidus deep brain stimulation (GP DBS).
  • To compare these findings with previously reported effects of subthalamic nucleus deep brain stimulation (STN DBS) on verbal fluency.
  • To determine if GP DBS offers greater flexibility in programming due to potential differences in sensitivity to stimulation location.

Main Methods:

  • Patient-specific deep brain stimulation (DBS) models were constructed for individuals receiving globus pallidus stimulation.
  • The volume of tissue activated (VTA) within the globus pallidus was calculated for each patient.
  • Verbal fluency performance was assessed and correlated with stimulation contact locations (dorsal, optimal, ventral) within the globus pallidus.

Main Results:

  • Unlike findings in the subthalamic nucleus, no significant correlation was observed between stimulation location and verbal fluency performance in patients receiving globus pallidus deep brain stimulation.
  • The volume of tissue activated did not significantly influence verbal fluency outcomes based on stimulation contact.

Conclusions:

  • Verbal fluency appears less sensitive to the precise stimulation location within the globus pallidus compared to the subthalamic nucleus.
  • Globus pallidus deep brain stimulation may offer greater flexibility in programming parameters without adversely affecting verbal fluency.
  • These findings suggest potential advantages for GP DBS in managing Parkinson's disease, particularly regarding cognitive side effect profiles.