Are hand-held TCD measurements acceptable for estimates of CBFv?

Cerebral blood flow velocity (CBFv) and the autoregulation index (ARI) can be reproducibly assessed by noninvasive transcranial Doppler (TCD) methodology using frame-held (FH) ultrasound probes. However, FH techniques may be impractical in severe head injury patients and neonates, where CBFv and ARI estimates are an important component of clinical assessment and management. Therefore, the aim of this study was to investigate the feasibility of an alternative hand-held (HH) approach to CBFv and ARI measurement. In a healthy volunteer population of 11 subjects, mean age 37 years, CBFv and ARI estimates were not significantly different between HH and FH acquisition techniques. In addition, in the hands of a single observer, good reproducibility over two visits, a mean of 6 days apart, was observed: intra-visit coefficient of variation (CV) 5.3% and 15.8%; and intraclass correlation coefficient (ICC) 0.8 and 0.4 for CBFv and ARI, respectively. Further work is required to assess the use of alternative sites to the middle cerebral artery (MCA) for the assessment of CBFv and ARI using HH rather than FH techniques and the applicability of this methodology in patient populations.