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Iron, infection, and the role of bicarbonate
J J Bullen1, C G Ward, H J Rogers
1University of Miami School of Medicine, Department of Surgery, FL 33101.
FEMS Microbiology Letters
|September 1, 1990
Abstract:
Ferric iron will not saturate transferrin in Tris buffer, and its use in experimental infections has been criticized. However, in the presence of bicarbonate, as in plasma, saturation occurs rapidly. This is comparable to natural iron overload, and infections.