Related Experiment Video
Updated: May 20, 2026
05:43
Topical Airway Anesthesia for Awake-endoscopic Intubation Using the Spray-as-you-go Technique with High Oxygen Flow
Published on: January 13, 2017
[Lidocaine in endotracheal intubation]
1Service d’anesthesie reanimation C.H.U Gabriel Toure, Bamako, Mali.
Le Mali Medical
|July 7, 2012
Summary
Intravenous lidocaine, administered before endotracheal intubation, effectively prevents hypertension. This includes lidocaine used alone or with fentanyl, offering a safer intubation process.
Area of Science:
- Anesthesiology
- Pharmacology
Context:
- Endotracheal intubation is a critical procedure often associated with hemodynamic instability.
- Hypertension is a common complication during intubation and surgical incision.
Purpose:
- To evaluate the efficacy of intravenous lidocaine in mitigating the hypertensive response to endotracheal intubation.
- To compare the effects of lidocaine alone versus lidocaine in combination with fentanyl.
Summary:
- A randomized prospective study involving three groups of patients undergoing endotracheal intubation.
- Group I received fentanyl, penthotal, and vecuronium. Group II received lidocaine, fentanyl, penthotal, and vecuronium. Group III received lidocaine, penthotal, and vecuronium.
- Both lidocaine groups (II and III) demonstrated significantly lower mean arterial pressure during intubation and incision compared to the control group (I).
Impact:
- Intravenous lidocaine is a valuable tool for blunting the pressor response to endotracheal intubation.
- This strategy can improve patient safety by preventing peri-intubation hypertension.
- Findings support the routine use of lidocaine in anesthetic protocols for intubation.
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