Related Experiment Video

Updated: May 20, 2026

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
06:47

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation

Published on: January 28, 2021

Lipoprotein status among urban populations in Bangladesh

Sumon Kumar Das1, Abu Syed Golam Faruque, Ashish Kumar Chowdhury

  • 1International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Bangladesh.

Atherosclerosis
|July 7, 2012
PubMed

Insights

Serum lipoprotein levels, particularly total cholesterol and LDL, are highest in urban Bangladeshi adults aged 30-39, increasing microvascular disease risk. Further studies are needed to confirm these findings in rural populations.

Area of Science:

  • Cardiovascular epidemiology
  • Clinical biochemistry
  • Public health research

Background:

  • Serum lipoprotein levels are critical predictors of microvascular diseases.
  • Urbanization may influence lipoprotein profiles.
  • Data on age-specific lipoprotein status in urban Bangladeshi populations are scarce.

Purpose of the Study:

  • To analyze age-specific serum lipoprotein levels in an urban Bangladeshi population.
  • To identify age groups with elevated lipoprotein concentrations.
  • To assess the relationship between age and lipoprotein levels in relation to microvascular disease risk.

Main Methods:

  • Analysis of de-identified serum lipoprotein data from 51,353 individuals in urban Bangladesh (2005-2011).
  • Data extracted from the Clinical Biochemistry Laboratory Data Archive at icddr,b.
  • Individuals categorized into six age groups for comparative analysis.

Main Results:

  • Adults aged 30-39 years exhibited significantly higher mean serum levels of total cholesterol (TC), LDL, triglycerides (TG), and TC:HDL and LDL:HDL ratios compared to other age groups.
  • The prevalence of high TC and LDL varied significantly between 2005 and 2011 in the 30-39 age group.

Conclusions:

  • Individuals aged 30-39 years in urban Bangladesh show elevated lipoprotein concentrations, correlating with increased microvascular disease risk.
  • Further population-based studies are recommended to validate these findings in rural Bangladeshi settings.
Abstract

Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Formation of Lipopolysaccharides01:19

Formation of Lipopolysaccharides

Lipopolysaccharides (LPS) are crucial components of the outer membrane of Gram-negative bacteria, serving both structural and functional roles. It contributes to membrane stability and protects bacteria from host immune responses. LPS is composed of three major regions—lipid A, a core oligosaccharide, and an O antigen. The biosynthesis and assembly of LPS involve a highly coordinated set of enzymatic reactions and transport mechanisms. Additionally, LPS is recognized as an endotoxin, triggering...
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Lipid Absorption01:24

Lipid Absorption

Dietary triglycerides from chyme in the duodenum are mixed with bile salts produced by the liver to emulsify fats. As a result, large droplets are broken down into smaller ones, increasing the surface area for enzymatic action. Once emulsified, pancreatic lipases hydrolyze the triglycerides into free fatty acids and monoglycerides.
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...