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Updated: May 20, 2026

Studying Effects of Cigarette Smoke on Pseudomonas Infection in Lung Epithelial Cells
Published on: May 11, 2020
What was the first epidemiological study of smoking and lung cancer?
1Department of Preventive Medicine, Keck School of Medicine, USC Institute for Global Health, University of Southern California, 2001 N Soto St, Suite 330A, MC9239, Los Angeles, CA 90089-9239, USA. jsamet@med.usc.edu
Abstract:
Based on his critique of the early case-control study of smoking and lung cancer by Mueller, Morabia questions the priority that has been assigned to this research. I examine Morabia's approach to retrospectively assess quality and question its general applicability and replicability. By citation analyses, the case-control studies published in the 1950s have had far greater impact. Morabia's commentary points to the complexity and subtlety of re-interpreting older literature.
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