Related Experiment Video
Updated: May 20, 2026
Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits (Oryctolagus cuniculus)
Published on: July 31, 2021
[Reversible immunosuppression, liver and kidney markers, calcium and phosphorus in the healthy rabbit]
Félix Yapi Houphouet1, Adou Yapo, Dit Phillipe Bidié Alain
1Laboratoire de Pharmacodynamie-Biochimique, UFR Biosciences, Universite de Cocody-Abidjan, Cote d’Ivoire, Abidjan. felhouph@yahoo.fr
Aim:
The aim of this study was to determine one or several doses of Methylprednisolone ( MP) who leads a long time of immunosuppression without disrupting phosphor and calcium, liver and kidney markers at the healthy rabbit.
Material And Methods:
This study was made to fifteen rabbit. Five (5) batches were constituted according to Nacl and Methylpredmisolone administered dose by body weight. Control batch ( Nacl 0,9%); batch I (2,5mg / kg MP); batch II ( 5mg / kg MP); batch III ( 10mg / kg MP) and batch IV ( 15 mg / kg MP). Biochemical parameters were measured by chemical and enzymatic methods.
Results:
The results of this study showed an immunosuppression during seven days with 10 and 15 mg / kg of MP doses (P < 0.05). The biochemical disturbances were only observed with 15 mg / kg dose where calcium was lowered to day 15 and TGO increased to day 3 according to day 0 (P < 0.05).
Conclusion:
This study showed that the doses which lead a long time of immunosuppression ( 7 days) are 10 and 15 mg / kg of MP, then the dose which does not disrupt the biochemical parameters is 10 mg / kg of MP.
