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POEMS syndrome: a case report.

M Bisail1, A Cossu, G Massarelli

  • 1Department of Medicine, University of Sassari, Italy.

Haematologica
|July 1, 1990
PubMed
Summary

This case study details POEMS syndrome in a 43-year-old male, highlighting polyneuropathy, bone lesions, skin changes, and organ enlargement. A unique observation was hemiparesis without apparent vascular cause.

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Area of Science:

  • Neurology
  • Hematology
  • Dermatology

Background:

  • POEMS syndrome is a rare multisystem disorder.
  • It is characterized by polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes.
  • This case presents a unique constellation of symptoms and findings.

Observation:

  • A 43-year-old male presented with POEMS syndrome.
  • Key features included polyneuropathy, an osteolytic lesion, scleroderma-like skin changes, lymphadenopathy, and hepatosplenomegaly.
  • A peculiar finding was the development of right hemiparesis without identified vascular disease.

Findings:

  • Liver biopsy revealed regenerative changes without necrosis.
  • The patient had a solitary IgA-lambda plasmacytoma causing the osteolytic lesion.

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  • The hemiparesis was an unusual neurological manifestation in this context.

    • Implications:

    • This case underscores the complex and varied presentations of POEMS syndrome.
    • Understanding the links between diverse POEMS features is crucial for diagnosis and management.
    • Further research into the pathogenesis of neurological complications like hemiparesis in POEMS is warranted.