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Related Concept Videos

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
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Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Dialysis01:15

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...

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Related Experiment Video

Updated: May 20, 2026

Isolation, Characterization, and Proteomic Analysis of Plasma-Derived Extracellular Vesicles for Cardiovascular Biomarker Discovery
05:30

Isolation, Characterization, and Proteomic Analysis of Plasma-Derived Extracellular Vesicles for Cardiovascular Biomarker Discovery

Published on: January 31, 2025

Therapeutic plasmapheresis using membrane plasma separation.

Aditi Sinha1, Anand Narain Tiwari, Rahul Chanchlani

  • 1Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India.

Indian Journal of Pediatrics
|July 7, 2012
PubMed
Summary
This summary is machine-generated.

Therapeutic plasmapheresis (TPE) using membrane filters is safe and effective for pediatric patients with kidney diseases like atypical hemolytic uremic syndrome. This study shows TPE successfully treated most patients, demonstrating its feasibility in a referral center setting.

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Area of Science:

  • Nephrology
  • Pediatric Nephrology
  • Membrane Filtration Technology

Background:

  • Therapeutic plasmapheresis (TPE) is a crucial treatment for various pediatric kidney diseases.
  • Membrane filtration offers a modern approach to TPE, but its application in pediatric settings requires careful evaluation.
  • Experience with TPE using membrane filters in pediatric patients is limited.

Purpose of the Study:

  • To evaluate the safety, efficacy, and feasibility of therapeutic plasmapheresis (TPE) utilizing membrane filtration in pediatric patients.
  • To assess the outcomes of TPE for specific pediatric renal conditions, including atypical hemolytic uremic syndrome (HUS), crescentic glomerulonephritis, and focal segmental glomerulosclerosis.
  • To document the adverse events associated with TPE in this pediatric cohort.

Main Methods:

  • Retrospective analysis of 486 TPE sessions performed between January 2006 and December 2010.
  • Inclusion of 39 pediatric patients (ages 6-17 years) treated at a referral center's pediatric dialysis unit.
  • Focus on TPE procedures employing membrane filters.

Main Results:

  • A satisfactory treatment response was observed in 32 out of 39 patients (82%).
  • High efficacy was noted particularly in patients with atypical hemolytic uremic syndrome (22/22) and crescentic glomerulonephritis (6/8).
  • Adverse effects were generally mild and manageable, including chills/urticaria (8 sessions), hypocalcemia (6 sessions), and hypotension (5 sessions).

Conclusions:

  • Therapeutic plasmapheresis using membrane filtration is a safe and effective treatment modality for pediatric patients with specific kidney diseases.
  • The procedure demonstrates feasibility within a pediatric dialysis unit setting.
  • TPE is a valuable therapeutic option for managing severe pediatric renal conditions like HUS and glomerulonephritis.