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Role of microRNAs in peripheral artery disease (review)

Xiangyu Zhou1, Ping Yuan, Yanzheng He

  • 1Department of Vascular Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou, Sichun, PR China. xiangyuzhou971@gmail.com

Molecular Medicine Reports
|July 7, 2012
PubMed

Insights

Peripheral arterial disease (PAD) is linked to atherosclerosis and neointimal lesions. This review explores how microRNAs (miRNAs) regulate vascular cell functions and their role in PAD development.

Area of Science:

  • Vascular Biology
  • Molecular Medicine
  • Genetics

Background:

  • Peripheral arterial disease (PAD) is a manifestation of systemic atherosclerosis, characterized by neointimal lesion formation due to aberrant vascular smooth muscle cell proliferation.
  • The precise molecular mechanisms governing PAD pathogenesis are not fully elucidated.
  • MicroRNAs (miRNAs), small non-coding RNAs, are emerging as key regulators of gene expression.

Purpose of the Study:

  • To review and summarize the current understanding of specific microRNAs (miRNAs) involved in the pathological processes of peripheral arterial disease (PAD).
  • To highlight the critical roles of miRNAs in modulating vascular cell functions relevant to PAD.

Main Methods:

  • Literature review of studies investigating the role of miRNAs in peripheral arterial disease (PAD).
  • Analysis of findings on miRNA regulation of vascular smooth muscle cell proliferation, migration, differentiation, apoptosis, and contraction.

Main Results:

  • Specific miRNAs have been identified as critical modulators in the development of PAD.
  • These miRNAs influence key vascular cell functions, including proliferation and apoptosis, contributing to neointimal lesion formation.
  • miRNAs represent a significant regulatory layer in the molecular pathology of PAD.

Conclusions:

  • MicroRNAs play a crucial role in the molecular mechanisms underlying peripheral arterial disease (PAD).
  • Understanding miRNA involvement offers potential therapeutic targets for PAD treatment.
  • Further research into miRNA-mediated pathways is essential for advancing PAD management.

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