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MRP3 gene expression correlates with NRF2 mutations in lung squamous cell carcinomas

Hidefumi Sasaki1, Masayuki Shitara, Keisuke Yokota

  • 1Department of Oncology, Immunology and Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan. hisasaki@med.nagoya-cu.ac.jp

Molecular Medicine Reports
|July 7, 2012
PubMed
Summary

Multidrug-resistant protein-3 (MRP3) expression is higher in male lung squamous cell carcinoma patients and correlates with NRF2 mutations. This suggests NRF2 activation may induce MRP3 expression in lung cancer.

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