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Related Concept Videos

Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
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Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
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Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
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The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic symptoms in all...
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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...

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Related Experiment Video

Updated: May 20, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

A framework to avoid irrational polypharmacy in psychiatry.

Daniel Zigman1, Pierre Blier

  • 1University of Ottawa Institute for Mental Health Research, Ottawa, ON, Canada.

Journal of Psychopharmacology (Oxford, England)
|July 7, 2012
PubMed
Summary
This summary is machine-generated.

Rational combination therapy can improve psychiatric treatment outcomes for patients with treatment-resistant mental illnesses. This framework helps clinicians avoid irrational polypharmacy by considering drug interactions and appropriate dosing.

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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
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Published on: December 11, 2016

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Last Updated: May 20, 2026

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Therapeutics

Background:

  • Many patients with psychiatric disorders do not achieve remission with standard treatments.
  • Treatment resistance is a significant challenge in managing serious mental illnesses.
  • The use of combination therapy is increasingly recognized for complex cases.

Purpose of the Study:

  • To present a framework for the rational use of combination therapy in psychiatric treatment.
  • To guide clinicians in avoiding irrational polypharmacy.
  • To optimize treatment outcomes for patients with treatment-resistant mental illnesses.

Main Methods:

  • The study outlines key considerations for combination therapy.
  • These include evaluating pharmadynamic redundancy and interactions.
  • It also emphasizes pharmacokinetic interactions, appropriate dosing, and regular reassessment.

Main Results:

  • A structured approach can prevent irrational polypharmacy.
  • Careful consideration of drug interactions and dosing is crucial.
  • Regular reassessment ensures continued benefit and need for therapy.

Conclusions:

  • Rational combination therapy offers a viable strategy for treatment-resistant psychiatric disorders.
  • A systematic framework aids clinicians in prescribing multiple medications safely and effectively.
  • This approach aims to improve patient remission rates and therapeutic outcomes.