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Sensory neuro-immune interactions differ between irritable bowel syndrome subtypes

Patrick A Hughes1, Andrea M Harrington, Joel Castro

  • 1Nerve-Gut Research Laboratory, Discipline of Medicine, Faculty of Health Sciences, The University of Adelaide and Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, South Australia, Australia 5000.

Gut
|July 7, 2012
PubMed
Summary

Irritable bowel syndrome (IBS) involves immune dysfunction that differs between diarrhea-predominant IBS (D-IBS) and constipation-predominant IBS (C-IBS) patients, impacting sensory nerves differently. Targeting specific immune pathways may benefit distinct IBS subgroups.

Keywords:
2,4,6-trinitrobenzene sulphonic acidHelicobacter Pylori—epidemiologyIrritable bowel syndromecytokinefunctional bowel disorderfunctional dyspepsiagastro-oesophageal reflux diseaselower oesophageal sphincternerve—gut interactionsneurogastroenterologypainreal time PCRsensory neuronsvisceral hypersensitivityvisceral nociception

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