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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
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Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...

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Related Experiment Video

Updated: May 20, 2026

Transcanalicular Diode Laser-assisted Dacryocystorhinostomy for the Treatment of Primary Acquired Nasolacrimal Duct Obstruction
07:30

Transcanalicular Diode Laser-assisted Dacryocystorhinostomy for the Treatment of Primary Acquired Nasolacrimal Duct Obstruction

Published on: October 13, 2017

Acute dacryoadenitis in Crohn's disease.

Vijay Wagh1, S V Raman, R Parrish

  • 1Royal Eye Infirmary, Plymouth Hospital NHS Trust, Plymouth, Devon, UK.

BMJ Case Reports
|July 7, 2012
PubMed
Summary
This summary is machine-generated.

A patient with Crohn's disease experienced acute painful red eye and blurred vision. Imaging revealed lacrimal gland enlargement, resolving with conservative management.

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Published on: January 24, 2020

Area of Science:

  • Ophthalmology
  • Immunology
  • Gastroenterology

Background:

  • Crohn's disease is a chronic inflammatory condition with potential extraintestinal manifestations.
  • Ocular involvement in Crohn's disease is uncommon but can present with diverse pathologies.

Observation:

  • A 48-year-old female with a history of Crohn's disease presented with acute unilateral painful red eye, blurred vision, and periorbital swelling.
  • Ocular examination revealed decreased visual acuity, conjunctival chemosis, and restricted ocular motility.
  • Laboratory tests showed elevated inflammatory markers (erythrocyte sedimentation rate and C-reactive protein).

Findings:

  • Contrast-enhanced CT scan confirmed enlargement of the lacrimal gland.
  • Microbiological investigations (blood culture, conjunctival swab) were negative, ruling out infection.
  • The patient's symptoms were managed conservatively with analgesics.

Implications:

  • This case highlights lacrimal gland enlargement as a potential, albeit rare, ocular manifestation of Crohn's disease.
  • Conservative management can be effective for this condition, avoiding the need for more invasive treatments.
  • Further research may elucidate the immunopathogenic mechanisms linking Crohn's disease and lacrimal gland inflammation.