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Mast cell activation in sterile bladder and prostate inflammation
T C Theoharides1, N Flaris, C T Cronin
1Department of Pharmacology, Tufts University School of Medicine-New England Medical Center, Boston, Mass.
International Archives of Allergy and Applied Immunology
|January 1, 1990
Summary
This study reports a middle-aged man with chronic bladder pain and hematuria, linked to increased bladder and prostate mast cells. Findings suggest mast cell degranulation without exocytosis may contribute to interstitial cystitis (IC) symptoms.
Area of Science:
- Urology
- Immunology
- Pathology
Background:
- Interstitial cystitis (IC) is a chronic bladder condition of unknown cause, often linked to sterile inflammation and increased bladder mast cells.
- IC predominantly affects women, with no effective therapies currently available.