Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Overview of the Vascular System01:20

Overview of the Vascular System

The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cats infected with H5N1 avian influenza - a new infectious disease in Poland.

Polish journal of veterinary sciences·2025
Same author

Identification of linear epitopes on the flagellar proteins of Clostridioides difficile.

Scientific reports·2021
Same author

The impact of a single whole body cryostimulation treatment on selected skin properties of healthy young subjects.

Cryobiology·2021
Same author

Skin lymphatic system in the pathogenesis of arterial hypertension - review and critique.

Lymphology·2020
Same author

The effect of vitamin D supplementation on the muscle damage after eccentric exercise in young men: a randomized, control trial.

Journal of the International Society of Sports Nutrition·2020
Same author

Alterations of aorta intima and media transcriptome in swine fed high-fat diet over 1-year follow-up period and of the switch to normal diet.

Nutrition, metabolism, and cardiovascular diseases : NMCD·2020
Same journal

Can Knowledge and Motivation for Lymphedema Self-Management Be Improved with the Use of ICG Lymphography? A Prospective Observational Repeated Measures Study.

Lymphology·2026
Same journal

The Burden of Breast Cancer-Related Lymphedema on Upper Extremity Functionality: A Comparative Analysis with Healthy Controls and Across Disease Stages.

Lymphology·2026
Same journal

Lymphspiration: Contractility of Thoracic Duct - What Do We Know and What is Still to Be Discovered?

Lymphology·2026
Same journal

Responsiveness and Minimal Clinically Important Changes for the Upper Limb Functional Index, Shoulder Pain and Disability Scale, and Lymphedema Life Impact Scale in Patients with Lymphedema.

Lymphology·2026
Same journal

Investigation of Bioimpedance Capacitance in Patients with Breast Cancer-Related Lymphedema on the Basis of Weibull Analysis.

Lymphology·2026
Same journal

Digital Experts in Lymphedema: Assessing the Quality and Readability of Responses from ChatGPT and Gemini.

Lymphology·2026
See all related articles

Related Experiment Video

Updated: May 20, 2026

Flow Cytometry Analysis of Immune Cells Within Murine Aortas
15:15

Flow Cytometry Analysis of Immune Cells Within Murine Aortas

Published on: July 1, 2011

Adventitial lymphatics and atherosclerosis.

K Drozdz1, D Janczak, P Dziegiel

  • 1Department of Internal Medicine, Wroclaw Medical University, Wroclaw, Poland.

Lymphology
|July 10, 2012
PubMed
Summary
This summary is machine-generated.

Adventitial lymphatic vessels are present in human arteries. Their numbers increase with atherosclerosis progression, correlating with intimal thickness and subject age.

More Related Videos

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Related Experiment Videos

Last Updated: May 20, 2026

Flow Cytometry Analysis of Immune Cells Within Murine Aortas
15:15

Flow Cytometry Analysis of Immune Cells Within Murine Aortas

Published on: July 1, 2011

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
09:55

Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

Published on: October 25, 2024

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
05:51

A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology

Published on: May 6, 2014

Area of Science:

  • Cardiovascular Biology
  • Vascular Biology
  • Immunology

Background:

  • Lymphatic vessels are vital for reverse cholesterol transport and atherosclerotic plaque regression in animal models.
  • Understanding lymphatic vessel roles in human atherosclerosis is crucial.

Purpose of the Study:

  • To analyze adventitial microcirculation, including lymphatic vessels and macrophages, in human arteries across different atherosclerosis stages.
  • To investigate the relationship between adventitial lymphatics and atherosclerotic progression.

Main Methods:

  • Examined 81 human arterial segments (iliac arteries, abdominal aortas) from organ donors.
  • Used immunohistochemistry (anti-LYVE-1, anti-D2-40/podoplanin, anti-CD-31, anti-CD-68) to identify lymphatic vessels, blood vessels, and macrophages.
  • Quantified intimal thickness and adventitial vessels; performed statistical analysis (Mann-Whitney, F-Cox, Chi-square, Spearman's correlation).

Main Results:

  • Identified and quantified lymphatic and blood vessels in the adventitia of large human arteries.
  • Found significant positive correlations between adventitial lymphatic vessel count and intimal thickness (r=0.37, p<0.05).
  • Observed a significant positive correlation between adventitial lymphatic vessel count and subject age (r=0.3, p<0.05).

Conclusions:

  • Lymphatic vessels are present in the adventitia of large human arteries.
  • The number of adventitial lymphatic vessels increases with the progression of atherosclerosis, indicated by intimal thickness.
  • Adventitial lymphatics may play a role in the pathogenesis of human atherosclerosis.