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Peptide YY in children: a review

Janet M Wojcicki1

  • 1Department of Pediatrics, University of California, 500 Parnassus Ave MU 4E, San Francisco, CA 94134-0136, USA. wojcicki@gmail.com

Journal of Pediatric Endocrinology & Metabolism : JPEM
|July 10, 2012
PubMed

Insights

Peptide YY (PYY) levels are higher in newborns than adults, with childhood PYY patterns becoming similar to adults as children age. Further research is needed on PYY

Area of Science:

  • Pediatric Endocrinology
  • Neuroscience
  • Metabolic Research

Background:

  • Peptide YY (PYY) is known to reduce food intake through the vagal-brainstem-hypothalamic pathway.
  • Existing research suggests potential differences in PYY levels during early childhood compared to adult studies.
  • A comprehensive synthesis of PYY studies in children has been lacking.

Purpose of the Study:

  • To synthesize existing research on Peptide YY (PYY) levels in pediatric populations.
  • To compare PYY levels and their associations in children versus adults.
  • To identify knowledge gaps regarding PYY's role in child development and health.

Main Methods:

  • Systematic review and synthesis of 21 relevant scientific articles.
  • Inclusion of studies encompassing infants, newborns, primary school-aged children, and children with special health needs.

Main Results:

  • Infants and newborns exhibit significantly higher PYY levels compared to older children and adults.
  • The association between PYY levels, body composition, and obesity in children increasingly resembles adult patterns with age.
  • Fasting PYY levels may be lower in obese children than adults, and weight loss might restore higher postprandial PYY levels, unlike in adults.

Conclusions:

  • Further investigation is required to elucidate the significance of elevated PYY levels in infancy.
  • Additional research should assess the impact of various dietary interventions on children's PYY levels across different developmental stages.
  • Future studies should consider diverse racial and ethnic backgrounds when examining PYY's role in pediatric growth and development.
Abstract

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