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Oxidative stress in obese children and its relation with insulin resistance

Ilker Tolga Ozgen1, Mehmet Emre Tascilar, Pelin Bilir

  • 1Division of Pediatric Endocrinology, Department of Pediatrics, Bezm-i Alem Vakif University, Istanbul, Turkey. drtolgaozgen@yahoo.com

Journal of Pediatric Endocrinology & Metabolism : JPEM
|July 10, 2012
PubMed

Insights

Obese children show oxidative stress, with higher nitrite/nitrate and lower glutathione peroxidase levels linked to insulin resistance (IR). These markers correlate with HOMA-IR, indicating a connection between oxidative stress and IR in pediatric obesity.

Area of Science:

  • Pediatric Endocrinology
  • Oxidative Stress Research
  • Metabolic Syndrome Studies

Background:

  • Obesity is linked to oxidative stress, a key factor in diseases like diabetes and atherosclerosis.
  • Investigating oxidative stress markers in obese children is crucial for understanding disease pathogenesis.
  • This study focuses on nitrite/nitrate and glutathione peroxidase levels in relation to insulin resistance (IR).

Purpose of the Study:

  • To assess oxidative stress status in obese children by measuring nitrite/nitrate and glutathione peroxidase levels.
  • To determine the relationship between these oxidative stress markers and insulin resistance (IR).
  • To explore the correlation of oxidative stress markers with HOMA-IR in pediatric obesity.

Main Methods:

  • A study involving 63 obese children divided into three groups: obese with IR, obese without IR, and a control group.
  • Measurements included nitrite/nitrate and glutathione peroxidase levels.
  • Statistical analysis, including multiple regression, was used to assess correlations with HOMA-IR, BMI, and other factors.

Main Results:

  • Obese children with IR exhibited lower glutathione peroxidase and higher nitrite/nitrate levels compared to controls and obese children without IR.
  • Nitrite/nitrate levels positively correlated with HOMA-IR, independent of BMI, age, gender, lipids, and pubertal status.
  • Glutathione peroxidase levels negatively correlated with BMI and HOMA-IR, independent of age, gender, pubertal status, and lipids.

Conclusions:

  • Oxidative stress is present in obese children.
  • Specific oxidative stress markers, nitrite/nitrate and glutathione peroxidase, are significantly related to insulin resistance (IR) in this population.
  • These findings highlight the role of oxidative stress in pediatric obesity and its association with IR, as indicated by HOMA-IR.
Abstract

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