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Preliminary study on subcortical slow potentials related to the readiness potential in monkey
1Institute of Psychology, University of Vienna, Austria.
Summary
This study mapped readiness potentials (RP) in rhesus monkeys, finding they occur in subcortical areas like the substantia nigra. This demonstrates the feasibility of tracking motor preparation signals in the brain.
Area of Science:
- Neuroscience
- Primate Research
- Electrophysiology
Background:
- Readiness potentials (RP) are electrophysiological signals reflecting motor preparation.
- Understanding RP distribution is crucial for mapping brain activity related to motor control.
- Subcortical involvement in motor preparation remains an area of active investigation.
Purpose of the Study:
- To determine the feasibility of mapping the intracerebral distribution of readiness potentials (RP) in non-human primates.
- To investigate subcortical areas involved in preparatory set using RP.
- To assess RP occurrence during self-paced operant responding.
Main Methods:
- Two female rhesus monkeys were implanted with cortical and subcortical DC-electrodes.
- Monkeys performed a self-paced operant conditioning task.
- Electrophysiological recordings of readiness potentials (RP) were analyzed during task performance.
Main Results:
- Comparable RPs were recorded from both monkeys, particularly during sessions with good performance.
- Large amplitude RPs were detected near the substantia nigra and pretectal/collicular regions.
- Smaller RPs were observed in the cortex, midbrain reticulum, and caudate nucleus (in one monkey).
Conclusions:
- Mapping intracerebral RP distribution is feasible in rhesus monkeys.
- Readiness potentials (RP) are present in multiple subcortical regions, including the substantia nigra.
- These findings suggest RP can serve as indicators of subcortical involvement in motor preparation.