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Identification of Kinase-substrate Pairs Using High Throughput Screening
11:13

Identification of Kinase-substrate Pairs Using High Throughput Screening

Published on: August 29, 2015

DUSPs, to MAP kinases and beyond.

Ching-Yu Huang1, Tse-Hua Tan

  • 1Immunology Research Center, National Health Research Institutes, Zhunan, Miaoli County, 35053, Taiwan. cyhuang@nhri.org.tw.

Cell & Bioscience
|July 10, 2012
PubMed
Summary
This summary is machine-generated.

Dual-specificity phosphatases (DUSPs) regulate intracellular signaling. This review covers DUSP regulation, T cell development roles, and potential links to cancer.

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Monitoring Kinase and Phosphatase Activities Through the Cell Cycle by Ratiometric FRET
13:38

Monitoring Kinase and Phosphatase Activities Through the Cell Cycle by Ratiometric FRET

Published on: January 27, 2012

Area of Science:

  • Biochemistry
  • Cell Biology
  • Immunology

Background:

  • Phosphatases regulate intracellular signaling pathways.
  • Dual-specificity phosphatases (DUSPs) dephosphorylate tyrosine and serine/threonine residues.
  • DUSPs are crucial in various biological processes, including T cell development.

Purpose of the Study:

  • To review the regulation and functions of typical DUSPs.
  • To summarize findings on DUSPs in T cell development using mouse models.
  • To explore DUSP roles in non-MAP kinase signaling and tumorigenesis.

Main Methods:

  • Literature review of DUSP research.
  • Analysis of data from DUSP-deficient mouse models.
  • Discussion of current research on DUSP targets and functions.

Main Results:

  • DUSPs are categorized into typical and atypical groups.
  • DUSP1/MKP1 regulates MAP kinase activity.
  • In vivo studies highlight DUSP involvement in T cell development and function.

Conclusions:

  • DUSP regulation and target interactions are complex.
  • DUSPs play significant roles in immune cell development.
  • Further research is needed to understand DUSP roles in cancer.