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Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report
Gabriella Aquino1, Renato Franco, Fioravante Ronconi
1Pathology Unit, National Cancer Institute Fondazione Giovanni Pascale, Via Mariano Semmola, 80131 Napoli, Italy.
Diagnostic Pathology
|July 10, 2012
Summary
Peripheral T-cell lymphomas not otherwise specified (PTCL-NOS) can show cyclin D1 overexpression due to gene copy gain, mimicking mantle cell lymphoma. Integrating molecular tests with histology is crucial for accurate PTCL-NOS diagnosis.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Peripheral T-cell lymphomas not otherwise specified (PTCL-NOS) are aggressive hematologic malignancies with poor prognosis.
- PTCL-NOS typically presents with complex karyotypes lacking specific genetic markers.
Observation:
- A case of PTCL-NOS exhibited heterogeneous nuclear cyclin D1 immunohistochemical overexpression.
- This overexpression was attributed to gene copy gain, a mechanism previously observed in mantle cell lymphoma.
Findings:
- Cyclin D1 overexpression in PTCL-NOS can be a diagnostic pitfall, potentially leading to misdiagnosis.
- The observed phenomenon resembles cyclin D1 overexpression in mantle cell lymphoma, often associated with t(11;14).
Implications:
- Accurate diagnosis of PTCL-NOS requires integrating classical histology and immunohistochemistry with molecular techniques.
- Molecular tests such as clonality assays and fluorescence in situ hybridization (FISH) are essential for definitive diagnosis.
- This case highlights the importance of comprehensive diagnostic approaches in challenging hematolymphoid neoplasms.
