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Simultaneous Monitoring of Wireless Electrophysiology and Memory Behavioral Test as a Tool to Study Hippocampal Neurogenesis
Published on: August 20, 2020
An old drug for new ideas: metformin promotes adult neurogenesis and spatial memory formation
Matthew B Potts1, Daniel A Lim
1Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Abstract:
Identifying well-tolerated, oral medications that enhance adult neurogenesis is of great clinical interest. In this issue of Cell Stem Cell, Wang et al. (2012) demonstrate that the diabetes medication metformin enhances spatial learning in mice by activating the atypical PKC/CBP pathway in adult neural stem cells.
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