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Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Tetraazacalix[2]arene[2]triazine modified silica gel: a novel multi-interaction stationary phase for mixed-mode
Wenjie Zhao1, Wenjing Wang2, Hong Chang2
1Key Laboratory of Chemical Biology and Organic Chemistry of Henan, Zhengzhou University, Zhengzhou 450052, China; School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China.
Abstract:
A novel multi-interaction and mixed-mode stationary phase based on tetraazacalix[2]arene[2]triazine modified silica (NCS) was synthesized and characterized by infrared spectra, elemental analysis and thermogravimetric analysis. Mechanism involved in the chromatographic separation is the multi-interaction including hydrophobic, π-π, hydrogen-bonding, inclusion and anion-exchange interactions. Based on these interactions, successful separation could be achieved among polycyclic aromatic hydrocarbons, aromatic position isomers, organic bases and phenols in reversed-phase chromatography. Inorganic anions were also shown to be individually separated in anion-exchange chromatography by using the same column. Moreover, the results here also demonstrated that NCS based stationary phase could effectively reduce the adverse effect of residual silanol in the separation process. Such stationary phase with characteristics of multi-interaction mechanism and mixed-mode separation is potential for the analysis of complex samples.
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