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Updated: May 20, 2026
Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
Published on: June 3, 2018
Turning cardiac fibroblasts into cardiomyocytes in vivo
1Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA. chunhui.xu@emory.edu
Abstract:
Murine fibroblasts have previously been reprogrammed to form cardiomyocytes in vitro, but recent studies have demonstrated direct conversion of cardiac fibroblasts into cardiomyocytes in vivo. This is accomplished by delivering transcription factors or microRNAs to the mouse heart and may represent a new avenue for regenerative cardiac therapy.
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