Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nose and Nasal Cavity

Nose and Nasal Cavity

The nose is composed of an observable exterior segment (external nose) and an internal segment within the skull known as the nasal cavity (internal nose). The external nose, visible on the face, consists of a framework of bone and hyaline cartilage enveloped in skin and muscle and lined with a mucous membrane. This structure is supported by the frontal bone, nasal bones, and maxillary bone and is supplemented by a cartilaginous framework comprising the septal nasal cartilage, lateral nasal...

Olfactory Receptors: Location and Structure

Olfactory Receptors: Location and Structure

The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...

Olfaction

Olfaction

The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...

Physiology of Smell and Olfactory Pathway

Physiology of Smell and Olfactory Pathway

Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...

Cranial Bones: Lateral View

Cranial Bones: Lateral View

The lateral view of the cranium is dominated by temporal, sphenoid, and ethmoid bones.
The temporal bone forms the lower lateral side of the skull. The temporal bone is subdivided into several regions. The flattened upper portion is the squamous portion of the temporal bone. Below this area and projecting anteriorly is the zygomatic process of the temporal bone, which forms the posterior portion of the zygomatic arch. Posteriorly is the mastoid portion of the temporal bone. Projecting...

Anatomy of Respiratory System I: Upper Respiratory Tract

Anatomy of Respiratory System I: Upper Respiratory Tract

The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Stapler-Assisted Pharyngeal Closure After Total Laryngectomy: A Systematic Review and Meta-Analysis.

Oncology and therapy·2022

Same author

Prevention of periprosthetic leakage with double flange voice prosthesis: a systematic review and management protocol proposal.

Logopedics, phoniatrics, vocology·2022

Same author

Relationship between allergic rhinitis and diamine oxidase activity: A preliminary report.

Allergologie select·2021

Same author

ENT emergencies during the first wave of COVID-19 pandemic in Spain: Our experience.

American journal of otolaryngology·2021

Same author

T1b Glottic Tumor and Anterior Commissure Involvement: Is the Transoral CO<sub>2</sub> Laser Microsurgery a Safe Option?

Ear, nose, & throat journal·2020

Same author

Chondroid tenosynovial giant cell tumour of the temporomandibular joint: A case report.

Acta otorrinolaringologica espanola·2020

Search research articles

Related Experiment Video

Updated: May 20, 2026

An Effective Manual Deboning Method To Prepare Intact Mouse Nasal Tissue With Preserved Anatomical Organization

An Effective Manual Deboning Method To Prepare Intact Mouse Nasal Tissue With Preserved Anatomical Organization

Published on: August 10, 2013

Nasal gel and olfactory cleft.

Jesús Herranz González-Botas¹, Anselmo Padín Seara

¹Servicio de Otorrinolaringología, Complejo Hospitalario Universitario A Coruña, A Coruña, España. jesus.herranz.gonzalez.botas@sergas.es

Acta Otorrinolaringologica Espanola

|July 10, 2012

Summary

Nasal gel administered via inhaler did not reach the olfactory cleft in healthy volunteers. Distribution was limited to the anterior nose, with some differences based on administration method.

Area of Science:

Otorhinolaryngology
Drug Delivery Systems
Nasal Anatomy

Background:

Intranasal drug delivery aims for targeted deposition, particularly in the olfactory cleft for systemic or central nervous system effects.
The efficacy of intranasal gels depends on their distribution within the nasal cavity.
Understanding deposition patterns is crucial for optimizing therapeutic outcomes.

Purpose of the Study:

To determine if intranasal gel, administered via a radial-hole inhaler, reaches the olfactory cleft.
To assess if different administration methods impact gel distribution within the nasal cavity.

Main Methods:

Sixteen healthy volunteers received intranasal gel in each nostril using different administration methods.
Nasal endoscopy was performed at 1 and 7 minutes post-administration to visualize gel deposition.

More Related Videos

A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation

A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation

Published on: August 18, 2014

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery

Published on: November 14, 2018

Related Experiment Videos

Last Updated: May 20, 2026

An Effective Manual Deboning Method To Prepare Intact Mouse Nasal Tissue With Preserved Anatomical Organization

An Effective Manual Deboning Method To Prepare Intact Mouse Nasal Tissue With Preserved Anatomical Organization

Published on: August 10, 2013

A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation

A Lateralized Odor Learning Model in Neonatal Rats for Dissecting Neural Circuitry Underpinning Memory Formation

Published on: August 18, 2014

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery

Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery

Published on: November 14, 2018

Gel presence was recorded in specific nasal regions: olfactory cleft, middle turbinate, middle meatus, nasal vestibule, inferior turbinate, septum, and inferior meatus.

Main Results:

No gel deposition was observed in the olfactory cleft, middle turbinate, or middle meatus.
Gel consistently localized to the nasal vestibule.
Significant differences in deposition rates were noted on the septum and inferior turbinate between the two administration methods.

Conclusions:

Current intranasal gel administration methods, including the radial-hole inhaler, do not effectively deliver medication to the olfactory cleft.
Gel distribution is primarily confined to the anterior and inferior nasal regions.
Administration technique influences deposition patterns in specific nasal areas like the septum and inferior turbinate.