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Related Concept Videos

Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
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Updated: May 20, 2026

Isolation and Culture of Neural Crest Cells from Embryonic Murine Neural Tube
12:48

Isolation and Culture of Neural Crest Cells from Embryonic Murine Neural Tube

Published on: June 2, 2012

The neural crest in vertebrate evolution.

Nicole M Le Douarin1, Elisabeth Dupin

  • 1Collège de France, 3 Rue d'Ulm, 75005 Paris, France. nicole.ledouarin@academie-sciences.fr

Current Opinion in Genetics & Development
|July 10, 2012
PubMed
Summary
This summary is machine-generated.

The vertebrate neural crest (NC) is crucial for head development and evolutionary success. Recent findings highlight its role in craniofacial skeletogenesis and unexpected regulation of brain development.

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Last Updated: May 20, 2026

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Area of Science:

  • Developmental Biology
  • Evolutionary Biology
  • Neuroscience

Background:

  • Vertebrates are chordates with a dorsal neural tube and notochord.
  • The vertebrate-specific neural crest (NC) is an embryonic, pluripotent cell population.
  • NC cells contribute to diverse cell types, significantly impacting vertebrate head formation and evolutionary success.

Purpose of the Study:

  • To discuss the contribution of the rostral neural crest to craniofacial skeletogenesis.
  • To highlight recent findings on the role of cephalic neural crest cells in brain development.

Main Methods:

  • Literature review and synthesis of existing data on neural crest function.
  • Analysis of studies focusing on craniofacial development and brain organization.

Main Results:

  • The rostral neural crest is a key contributor to craniofacial skeletogenesis.
  • Cephalic neural crest cells actively regulate secondary brain organizers.
  • This regulation is critical for preotic brain development, a previously unrecognized function.

Conclusions:

  • The neural crest is fundamental to vertebrate craniofacial and brain development.
  • The role of neural crest in brain development extends beyond skeletogenesis.
  • Understanding neural crest function provides insights into vertebrate evolution and congenital disorders.