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Anti-inflammatory effect of IMMLG5521, a coumarin derivative, on Sephadex-induced lung inflammation in rats
Zhipeng Li1, Jinfeng Hu, Mingna Sun
1State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Abstract:
The study is to investigate the effect of compound IMMLG5521, a coumarin derivative, on lung inflammation induced by Sephadex in rats. Sephadex led to massive granulomas, infiltration of neutrophils and eosinophils, the increase of TNF-α level in BALF and lung tissue. Sephadex injection led to the up-regulation of VCAM-1 and ICAM-1 expressions in the lungs. However, pretreatment with IMMLG5521 (6.25 and 12.5 mg/kg) inhibited massive granulomas and infiltration of neutrophils and eosinophils, decreased TNF-α level in BALF and lung tissue, and down-regulated VCAM-1 and ICAM-1 expressions in the lung tissue. In conclusion, compound IMMLG5521 may suppress the lung injury induced by Sephadex, at least in part, due to the prevention of the up-regulation of VCAM-1 and ICAM-1 expressions and TNF-α level.
