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Bioplastics

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...

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Updated: May 20, 2026

Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces

Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces

Published on: September 26, 2014

Surface properties of polyurethanes modified by bioactive polysaccharide-based polyelectrolyte multilayers.

Yifeng Wang¹, Qunfeng Hong, Yanjun Chen

¹School of Materials Science and Engineering, Wuhan University of Technology, Wuhan, PR China. yifengwang@whut.edu.cn

Colloids and Surfaces. B, Biointerfaces

|July 10, 2012

Summary

This summary is machine-generated.

This study developed a novel biomaterial coating using lentinan sulfate and chitosan on polyurethane surfaces. The modified material demonstrated reduced protein adsorption, improved cell compatibility, and antibacterial properties, suggesting potential for biomedical applications.

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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Published on: August 28, 2015

Area of Science:

Biomaterials Science
Polymer Chemistry
Surface Chemistry

Background:

Polyurethane (PU) is widely used in biomedical devices but can cause adverse biological responses.
Developing biocompatible and functional surface modifications is crucial for enhancing PU performance.
Polysaccharide-based coatings offer promising avenues for improving biomaterial properties.

Purpose of the Study:

To create a novel polysaccharide-based multilayer coating on polyurethane surfaces.
To evaluate the impact of this coating on surface properties, hemocompatibility, cytocompatibility, and antibacterial activity.
To explore the potential of layer-by-layer (LbL) assembly for advanced biomaterial development.

Main Methods:

Sulfation of lentinan from Lentinus edodes to obtain lentinan sulfate (LS).
Fabrication of LS/chitosan (CS) multilayers on PU using the LbL assembly technique.
Surface characterization using X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), and contact angle measurements.
In vitro assessment of fibrinogen adsorption, platelet adhesion, L-929 cell viability, and antibacterial activity against Pseudomonas aeruginosa.

Main Results:

The polysaccharide-based multilayers progressively decreased the water contact angle of PU surfaces.
Surface roughness increased with five bilayers of LS/CS, with LS as the top layer.
Fibrinogen adsorption was reduced by 81%, and platelet adhesion decreased significantly on the modified PU.
LbL-modified PU exhibited enhanced cytocompatibility with L-929 cells and demonstrated antibacterial activity against P. aeruginosa.

Conclusions:

The LbL assembly of lentinan sulfate and chitosan effectively modifies polyurethane surfaces.
The resulting coatings significantly improve hemocompatibility by reducing protein adsorption and platelet adhesion.
The modified PU surfaces show enhanced cytocompatibility and possess antibacterial properties, indicating their potential for biomedical applications.