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Influence of sleep on the cardiovascular and metabolic responses to a decrease in ambient temperature in lambs.

J E Fewell1, C S Kondo, V Dascalu

  • 1Department of Obstetrics and Gynaecology, University of Calgary, Canada.

Journal of Developmental Physiology
|April 1, 1990
PubMed
Summary

Sleep does not significantly impact cardiovascular and metabolic responses in young lambs to a moderate temperature drop. Nonshivering thermogenesis appears crucial during active sleep when shivering is absent.

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Area of Science:

  • Physiology
  • Neonatal Metabolism
  • Cardiovascular Regulation

Background:

  • Understanding how sleep states influence physiological responses to environmental stressors is crucial for neonatal care.
  • Young lambs are a relevant model for studying thermoregulation and metabolic adaptation due to their developmental stage.

Purpose of the Study:

  • To investigate the effects of different sleep states (quiet wakefulness, quiet sleep, active sleep) on cardiovascular and metabolic adjustments to a decrease in ambient temperature in neonatal lambs.
  • To determine if sleep alters thermogenic responses, oxygen consumption, and cardiovascular parameters during cold exposure.

Main Methods:

  • Seven lambs (10-24 days old) were instrumented for physiological monitoring, including electroencephalogram, electrooculogram, electromyogram, cardiac output, pressures, oxygen saturation, and body core temperature.

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  • Measurements were recorded during quiet wakefulness, quiet sleep, and active sleep at two ambient temperatures (25°C and 18°C).

    • Main Results:

    • A decrease in ambient temperature from 25°C to 18°C increased total body oxygen consumption similarly across all sleep states, indicating a consistent thermogenic response.
    • This increased metabolic demand was met by enhanced systemic oxygen transport and increased oxygen extraction.
    • Shivering was absent during active sleep, suggesting a significant role for nonshivering thermogenesis.

    Conclusions:

    • Sleep state does not significantly alter the cardiovascular and metabolic responses of young lambs to a modest decrease in ambient temperature.
    • Nonshivering thermogenesis is a key mechanism for metabolic heat production during active sleep in lambs exposed to cold.