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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...

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Related Experiment Video

Updated: May 20, 2026

Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

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Published on: March 2, 2020

Polymeric nucleic acid carriers: current issues and novel design approaches.

Han Chang Kang1, Kang Moo Huh, You Han Bae

  • 1Department of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 420-743, Republic of Korea.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|July 10, 2012
PubMed
Summary

Polymeric gene carriers are crucial for delivering nucleic acids like plasmid DNA (pDNA) and short interfering RNA (siRNA). This review explores challenges and solutions for effective gene delivery, focusing on overlooked factors.

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Last Updated: May 20, 2026

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Published on: March 2, 2020

High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
14:37

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Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry
08:51

Evaluation of Polymeric Gene Delivery Nanoparticles by Nanoparticle Tracking Analysis and High-throughput Flow Cytometry

Published on: March 1, 2013

Area of Science:

  • Biomaterials Science
  • Gene Therapy
  • Nanotechnology

Background:

  • Polymeric gene carriers are essential for delivering nucleic acids (e.g., plasmid DNA, short interfering RNA) in gene therapy.
  • Effective delivery requires overcoming extracellular and intracellular barriers encountered from administration to the target site.
  • Existing strategies often overlook critical factors influencing carrier performance and nucleic acid integrity.

Purpose of the Study:

  • To review extracellular and intracellular challenges in nucleic acid delivery using polymeric vectors.
  • To introduce strategies for overcoming these delivery hurdles.
  • To examine and highlight overlooked factors impacting gene delivery efficiency, such as microenvironmental pH, polymer/siRNA complexation, and formulation.

Main Methods:

  • Literature review of existing polymeric gene delivery systems and their challenges.
  • Analysis of critical, often overlooked, factors influencing nucleic acid delivery.
  • Discussion of novel approaches and reported strategies to address these factors.

Main Results:

  • Identification of key extracellular and intracellular barriers to nucleic acid delivery.
  • Elucidation of the significant impact of microenvironmental pH, polymer/siRNA complexation, and pharmaceutical formulation on delivery efficacy.
  • Presentation of innovative solutions and strategies to mitigate these challenges.

Conclusions:

  • Optimizing polymeric gene carriers requires a deep understanding of delivery hurdles and influencing factors.
  • Addressing overlooked parameters like pH, complexation, and formulation is critical for successful gene therapy.
  • The reviewed strategies offer promising avenues for enhancing the safety and efficacy of nucleic acid delivery systems.