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Updated: May 20, 2026

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
10:36

Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer

Published on: March 17, 2016

Endocrine resistance in breast cancer: from cellular signaling pathways to epigenetic mechanisms

Stéphanie Bianco1, Nicolas Gévry

  • 1Département de Biologie, Université de Sherbrooke, Sherbrooke, Québec, Canada.

Transcription
|July 10, 2012
PubMed

Insights

Genomic events causing endocrine resistance in breast cancer are unclear. This review merges signaling pathways with epigenetic studies, focusing on chromatin

Area of Science:

  • Oncology
  • Genomics
  • Epigenetics

Background:

  • Endocrine resistance is a major challenge in breast cancer treatment.
  • Existing cellular mechanisms do not fully explain endocrine resistance.
  • Genomic events leading to altered gene expression patterns remain poorly understood.

Purpose of the Study:

  • To review signaling pathways involved in endocrine resistance.
  • To integrate these pathways with recent epigenetic findings.
  • To elucidate the role of chromatin in estrogen receptor α (ERα) transcriptional dysregulation.

Main Methods:

  • Literature review of signaling pathways in endocrine resistance.
  • Analysis of recent epigenetic studies.
  • Integration of signaling pathways and epigenetic data.

Main Results:

  • Chromatin dynamics are crucial in the ERα transcriptional program.
  • Specific signaling pathways contribute to epigenetic alterations driving resistance.
  • A clearer understanding of genomic events underlying gene expression dysregulation is emerging.

Conclusions:

  • Epigenetic modifications, influenced by signaling pathways, play a significant role in endocrine resistance.
  • Understanding these integrated mechanisms is key to developing new therapeutic strategies for breast cancer.

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