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Updated: May 20, 2026
Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 25, 2016
Audiometric outcomes of topical IGF1 treatment for sudden deafness refractory to systemic steroids
Takayuki Nakagawa1, Eriko Ogino-Nishimura, Harukazu Hiraumi
1Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan. tnakagawa@ent.kuhp.kyoto-u.ac.jp
Objective:
To examine the effects of topically applied recombinant human insulin-like growth factor 1 (IGF1) via gelatin hydrogels on alterations in pure-tone audiometry (PTA) in patients with sudden sensorineural hearing loss (SSHL) refractory to systemic steroids.
Study Design:
Retrospective chart review.
Setting:
A single university hospital.
Patients:
Twenty-five patients with SSHL refractory to systemic steroids who received topical IGF1 treatment.
Intervention:
Single topical application of IGF1 to the round window niche using gelatin hydrogels.
Main Outcome Measures:
The primary outcome was alterations in PTA thresholds at frequencies of 0.25, 0.5, 1, 2, and 4 kHz after topical IGF1 application. Secondary outcomes included differences in final improvements in PTA thresholds among frequencies tested and cumulative numbers of patients showing 10- or 20-dB recovery in PTA during the observation period.
Results:
Topical IGF1 application via gelatin hydrogels significantly altered PTA thresholds at each frequency tested and at the average frequency. The numbers of patients with a 10-dB recovery in PTA increased until 4 weeks after treatment and then stabilized, whereas those patients showing 20-dB recovery gradually increased during the observation period.
Conclusion:
Topical IGF1 application via gelatin hydrogels contributes to the recovery of PTA levels in patients with SSHL refractory to systemic steroids. Major recovery of PTA levels occurs within 4 weeks after treatment.
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