Update on prostate pathology

This update on prostate pathology is very timely, as we celebrate the 20 anniversary of our great society, the International Society of Urological Pathologists (ISUP). Most of the key advances in this field over the past two decades have been made by several distinguished members of our society, as will be demonstrated herein. I am therefore indeed honored and privileged to be given the opportunity to present this paper. I will start with a brief historical perspective prior to delving into the update on prostate pathology over the past two decades and beyond. The topics discussed in this update will be somewhat limited, but will include The Gleason grading system; handling and staging of radical prostatectomy specimens; variants of prostatic adenocarcinoma; treatment effect on the prostate; other primary and secondary tumours involving the prostate, and biomarkers of prostate cancer.