Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ten-year outcomes for image-guided moderately hypofractionated proton therapy for prostate cancer.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncologyยท2026
Same author

Long-Term Outcomes of Consolidative Proton Therapy for Pediatric Classical Hodgkin Lymphoma.

International journal of particle therapyยท2026
Same author

A Systematic Study on Local Failure Events Post Chemoradiation Therapy for Cervical Cancer: Understanding the Impact of Baseline Lateral Anatomic Compartment Involvement.

International journal of radiation oncology, biology, physicsยท2025
Same author

Pattern of recurrence with 1.0ย cm CTV in brain glioblastoma treated with radiotherapy.

Journal of neuro-oncologyยท2025
Same author

Association Between Brain Substructure Dose and Scholastic Performance in Pediatric Brain Tumor Survivors Who Received Radiation Therapy.

International journal of radiation oncology, biology, physicsยท2025
Same author

Ethical Implications of Being a Holobiont.

Integrative and comparative biologyยท2025

Related Experiment Video

Updated: May 20, 2026

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Radiotherapy for spermatic cord sarcoma.

Ronica Hazariwala1, Christopher G Morris, Scott Gilbert

  • 1Departments of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL, USA.

American Journal of Clinical Oncology
|July 10, 2012
PubMed
Summary
This summary is machine-generated.

Spermatic cord sarcomas are rare. Proactive management with preoperative radiotherapy and resection is crucial for improving outcomes and reducing recurrence risk in these aggressive tumors.

More Related Videos

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Related Experiment Videos

Last Updated: May 20, 2026

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

Area of Science:

  • Oncology
  • Radiation Oncology
  • Surgical Oncology

Background:

  • Spermatic cord sarcomas are rare paratesticular tumors primarily affecting older men.
  • Current treatment relies on limited data, with surgery as the primary modality.
  • Local-regional recurrence rates after surgery are high, around 50%.

Purpose of the Study:

  • To evaluate the outcomes of spermatic cord sarcoma patients treated with radiation therapy.
  • To assess the impact of management strategies on local-regional control and survival.

Main Methods:

  • Retrospective review of 15 patients with intermediate to high-grade spermatic cord sarcomas treated with radiation (40-60 Gy).
  • Treatment fields included the scrotum, inguinal canal, and lower pelvic wall.
  • Analysis of outcomes based on surgical approach (exploration vs. planned resection) and radiotherapy timing (adjuvant vs. preoperative).

Main Results:

  • No local recurrences were observed in any patient.
  • Two regional nodal recurrences and one distant metastasis occurred, exclusively in patients with initial unplanned surgical exploration.
  • Five-year overall survival was 53%, with a cause-specific survival of 80%.
  • Complications were minimal, with only 4 grade 2 or 3 toxicities.

Conclusions:

  • Spermatic cord sarcomas, despite potential for non-disease related mortality, carry significant morbidity.
  • Optimizing initial management is critical to prevent local-regional contamination and recurrence.
  • Preoperative radiotherapy followed by definitive resection is recommended for proactive management, similar to other sarcoma sites.