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Related Concept Videos

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

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Related Experiment Video

Updated: May 20, 2026

Single-Cell RNA Sequencing of Mutant Whole Mouse Embryos: From the Epiblast to the End of Gastrulation
09:14

Single-Cell RNA Sequencing of Mutant Whole Mouse Embryos: From the Epiblast to the End of Gastrulation

Published on: June 14, 2024

Next-generation sequencing of experimental mouse strains.

Binnaz Yalcin1, David J Adams, Jonathan Flint

  • 1Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland. Binnaz.Yalcin@unil.ch

Mammalian Genome : Official Journal of the International Mammalian Genome Society
|July 10, 2012
PubMed
Summary

Sequencing diverse mouse genomes, beyond C57BL/6J, is crucial for genetic research. Advances in DNA sequencing are enabling this, paving the way to link mouse genome sequences to observable traits.

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Area of Science:

  • Genomics and Bioinformatics
  • Mammalian Genetics
  • Translational Research

Background:

  • Historically, only the C57BL/6J mouse strain genome sequence was available, limiting broad genetic studies.
  • This lack of genomic data for other common laboratory mouse strains hindered research utilizing these models.
  • Previous sequencing efforts enabled significant advances like large-scale genetic screens and genomic variation catalogs.

Purpose of the Study:

  • To review recent findings from expanded mouse genome sequencing projects.
  • To discuss the transition from mouse genome sequence data to understanding biological phenotypes.
  • To explore the future of de novo assembly for high-quality mouse genome sequences and required technological advancements.

Main Methods:

  • Review of published studies utilizing next-generation sequencing technologies for mouse genomes.
  • Analysis of findings linking genome sequences to phenotypic data.
  • Discussion of computational approaches, including de novo assembly, for genome sequencing.

Main Results:

  • Revolutionary DNA sequencing technologies have significantly expanded the number of fully sequenced mouse genomes.
  • These new sequences are crucial for understanding genotype-phenotype correlations in various mouse models.
  • Progress has been made in generating comprehensive genomic variation data across different mouse strains.

Conclusions:

  • The availability of multiple mouse genome sequences is accelerating biological discovery and translational research.
  • Future efforts should focus on high-quality de novo assembly and leveraging advanced sequencing technologies.
  • Understanding mouse genomic variation is key to bridging the gap between sequence and phenotype.