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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
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Related Experiment Video

Updated: May 20, 2026

Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation
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Published on: February 24, 2016

Selective non-covalent triggered release from liposomes.

Adam J Plaunt1, Meghan B Courbanou, Katrina D Cuison

  • 1Department of Chemistry and Biochemistry, 236 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN, USA.

Chemical Communications (Cambridge, England)
|July 10, 2012
PubMed
Summary

A zinc(II)-dipicolylamine complex binds to anionic liposomes, causing rapid release of their contents. This interaction occurs even with sterically protected liposomes, showing broad applicability.

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On-Chip Octanol-Assisted Liposome Assembly for Bioengineering
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Published on: February 24, 2016

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10:58

SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy

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On-Chip Octanol-Assisted Liposome Assembly for Bioengineering
09:45

On-Chip Octanol-Assisted Liposome Assembly for Bioengineering

Published on: March 17, 2023

Area of Science:

  • Coordination Chemistry
  • Materials Science
  • Drug Delivery Systems

Background:

  • Liposomes are widely used nanocarriers for drug delivery.
  • Controlling liposome stability and cargo release is crucial for effective therapeutics.
  • Anionic lipids can influence liposome interactions with biological molecules.

Purpose of the Study:

  • To investigate the interaction of a specific zinc(II)-dipicolylamine coordination complex with liposomes.
  • To determine if this complex can induce cargo release from liposomes.
  • To assess the selectivity of the complex for different types of liposomes, including PEGylated ones.

Main Methods:

  • Synthesis and characterization of the zinc(II)-dipicolylamine complex.
  • Preparation of anionic liposomes with varying lipid compositions.
  • Preparation of sterically protected PEGylated liposomes.
  • Assays to measure liposome association with the complex.
  • Leakage assays to quantify the release of encapsulated contents.

Main Results:

  • The zinc(II)-dipicolylamine complex selectively associated with anionic liposomes.
  • The complex induced rapid and significant leakage of encapsulated contents from these liposomes.
  • This association and subsequent leakage were observed even with sterically protected PEGylated liposomes, which are generally stable.
  • The interaction suggests a specific binding mechanism between the complex and the anionic lipid headgroups.

Conclusions:

  • Zinc(II)-dipicolylamine coordination complexes can act as effective agents for destabilizing and permeabilizing anionic liposomes.
  • This property holds potential for developing triggered release systems for liposome-encapsulated drugs.
  • The ability to disrupt even PEGylated liposomes opens avenues for overcoming stealth properties in targeted delivery.