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Related Concept Videos

Hybridoma Technology01:31

Hybridoma Technology

Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation, polyethylene glycol...
Drug Products: Biologics, Biosimilars and Interchangeables01:28

Drug Products: Biologics, Biosimilars and Interchangeables

Biologics, derived from living sources such as humans, animals, or microorganisms, represent a significant category of pharmaceuticals. These complex molecules, developed through advanced biotechnological methods or purified from natural sources, include essential medical treatments like insulin and growth hormones. The complexity of biologics arises from their large molecular structures and the intricate processes required for their production, making them distinct from conventional...
Antibody Actions01:26

Antibody Actions

Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
Humoral Immune Responses01:36

Humoral Immune Responses

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Related Experiment Video

Updated: May 20, 2026

Laboratory Scale Production and Purification of a Therapeutic Antibody
09:54

Laboratory Scale Production and Purification of a Therapeutic Antibody

Published on: January 24, 2017

Emerging antibody-based products.

Kevin J Whaley1, Josh Morton, Steve Hume

  • 1Mapp Biopharmaceutical Inc, 6160 Lusk Blvd, Suite C105, San Diego, CA, 92121, USA, Kevin.whaley@mappbio.com.

Current Topics in Microbiology and Immunology
|July 10, 2012
PubMed
Summary
This summary is machine-generated.

Plant virus-based expression offers a cost-effective and faster alternative for producing antibody-based products, addressing global health challenges. This technology enables scalable manufacturing with potential improvements in pharmacokinetics, safety, and efficacy.

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Last Updated: May 20, 2026

Laboratory Scale Production and Purification of a Therapeutic Antibody
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07:52

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Published on: September 10, 2018

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Immunology

Background:

  • Antibody production faces challenges including high costs, limited manufacturing capacity, and long lead times, hindering global health applications.
  • Revolutionary advances in plant virus-based transient expression present new opportunities to overcome these industrialization hurdles.

Purpose of the Study:

  • To review antibody-based products in development utilizing plant virus-based expression systems.
  • To highlight the manufacturing, purification, and potential advantages of these plant-derived antibodies.

Main Methods:

  • Focus on antibody products in preclinical and clinical development.
  • Review of scaled-up manufacturing and purification processes (mg of purified monoclonal antibody/kg of biomass).

Main Results:

  • Plant virus-based antibody products demonstrate lower upfront costs and reduced time to clinical and market supply.
  • These systems offer lower cost of goods (COGs) compared to traditional methods.
  • Plant-derived monoclonal antibodies (mAbs) show potential for improved pharmacokinetics, safety, and efficacy.

Conclusions:

  • Plant virus-based transient expression is a promising platform for addressing global health needs with antibody therapeutics.
  • This technology offers a scalable, cost-effective, and faster approach to antibody manufacturing.
  • Further development may lead to enhanced therapeutic properties and broader accessibility of antibody-based treatments.