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Updated: May 20, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

Published on: June 1, 2012

A minimally invasive microchip for transdermal injection/sampling applications.

Lucanos M Strambini¹, Angela Longo, Alessandro Diligenti

¹Dipartimento di Ingegneria dell'Informazione: Elettronica, Informatica, Telecomunicazioni, Università di Pisa, via G. Caruso 16, 56122, Pisa, Italy.

|July 10, 2012

Summary

This study introduces a novel silicon microchip with dense, hollow microneedles for transdermal fluid delivery and sampling. The device demonstrates robust penetration and controlled fluid flow for biomedical applications.

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Area of Science:

Biomedical Engineering
Materials Science
Nanotechnology

Background:

Minimally invasive technologies are crucial for efficient transdermal drug delivery and fluid sampling.
Existing methods often face challenges with pain, efficiency, and precise control.

Purpose of the Study:

To design, fabricate, and characterize a silicon microchip for transdermal injection and sampling.
To evaluate the mechanical stability and fluid dynamics of the microneedle array.

Main Methods:

Fabrication of a silicon microchip with a high-density array of hollow microneedles (1 million/cm²).
Mechanical testing using skin-like agarose hydrogels.
Fluid flow experiments with various liquids under controlled pressure differentials (10-100 kPa).

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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing

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Published on: June 1, 2012

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Analysis of liquid loss due to evaporation and acceleration.

Main Results:

Microneedles demonstrated successful penetration without breakage in 2% and 4% agarose hydrogels.
Fluid flow rate showed a linear dependence on pressure drop, controllable from ml/min to tens of ml/min.
Evaporation and acceleration losses were quantified at approximately 70 nl/min and 1300 nl/min, respectively.

Conclusions:

The developed silicon microchip with hollow microneedles is a viable platform for transdermal applications.
The device offers robust mechanical properties and precise fluid control for injection and sampling.
Further research can explore its potential in drug delivery and diagnostics.