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Severity of coronary artery disease affects prognosis of patients with peripheral artery disease

Takayuki Ishihara1, Osamu Iida, Atsushi Tosaka

  • 1Kansai Rosai Hospital Cardiovascular Center, Amagasaki, Japan. t.ishihara31@gmail.com

Angiology
|July 10, 2012
PubMed

Insights

Coronary artery disease (CAD) severity significantly impacts peripheral artery disease (PAD) patient outcomes. Patients with triple-vessel disease faced higher risks of death, major adverse cardiac events, and amputation compared to those with no or intermediate CAD.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Surgery
  • Interventional Cardiology

Background:

  • Prognostic impact of coronary artery disease (CAD) severity in peripheral artery disease (PAD) patients remains unclear.
  • PAD patients often have coexisting CAD, influencing their overall health outcomes.
  • Understanding this relationship is crucial for risk stratification and treatment planning.

Purpose of the Study:

  • To investigate whether the severity of coronary artery disease (CAD) influences the prognosis of patients with symptomatic peripheral artery disease (PAD).
  • To compare clinical outcomes across different CAD severity groups in PAD patients undergoing revascularization.

Main Methods:

  • Retrospective, multicenter analysis of 537 consecutive patients with symptomatic PAD.
  • Patients underwent peripheral artery revascularization and coronary angiography (CAG) prior to revascularization.
  • Classification into three groups based on CAG: no-CAD, intermediate CAD (1-2 diseased vessels), and triple-vessel disease (TVD).

Main Results:

  • The study included 204 patients in the no-CAD group, 268 in the intermediate CAD group, and 65 in the TVD group.
  • Mean follow-up was 952 days.
  • Freedom from adverse outcomes decreased significantly with increasing CAD severity: all-cause death (86% vs 77% vs 65%), MACE (95% vs 87% vs 78%), and amputation (96% vs 92% vs 83%).

Conclusions:

  • The severity of coronary artery disease (CAD) significantly affects the prognosis of patients with peripheral artery disease (PAD).
  • Triple-vessel disease (TVD) is associated with poorer outcomes, including higher rates of mortality, MACE, and amputation.
  • Risk stratification and tailored management strategies are warranted for PAD patients based on their CAD severity.

Keywords:
coronary artery diseaseperipheral artery diseaseprognosis

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