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Related Experiment Video

Updated: May 20, 2026

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents
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A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

Published on: July 16, 2020

Frameless navigated biopsy with the BrainLAB® VarioGuide system: a technical note.

Rüdiger Buchalla1, Silke Hopf-Jensen, Ortwin Rubarth

  • 1DIAKO Flensburg, Neurochirurgische Klinik, Flensburg, Germany. buchallaru@diako.de

Journal of Neurological Surgery. Part A, Central European Neurosurgery
|July 10, 2012
PubMed
Summary
This summary is machine-generated.

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This study shows the frameless BrainLAB® VarioGuide neuronavigation system is effective for brain biopsies, achieving a high diagnostic yield with no adverse events. The new system offers efficient and safe intracranial lesion targeting.

Area of Science:

  • Neurosurgery
  • Medical Technology
  • Neuropathology

Background:

  • Transition from frame-based to frameless stereotactic biopsy systems.
  • Introduction of the BrainLAB® VarioGuide neuronavigation system for improved brain biopsy procedures.

Purpose of the Study:

  • To evaluate the effectiveness and safety of the frameless BrainLAB® VarioGuide system for brain biopsies.
  • To analyze the diagnostic yield and procedural efficiency of the new neuronavigation tool.

Main Methods:

  • Retrospective analysis of the first 20 consecutive brain biopsy procedures using the BrainLAB® VarioGuide system.
  • Preoperative planning utilizing CT or MRI data.
  • Surgical procedures guided by frameless neuronavigation, with intraoperative neuropathological examination.

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Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
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Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

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Last Updated: May 20, 2026

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents
08:02

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

Published on: July 16, 2020

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
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Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

Main Results:

  • Successful harvesting of definitive pathological tissue in 18 out of 20 cases.
  • Mean operation time of 49 minutes, with system setup taking 5-10 minutes.
  • No adverse events reported during or after the procedures.

Conclusions:

  • The frameless BrainLAB® VarioGuide system is an effective and safe tool for brain biopsies.
  • The system facilitates efficient targeting and achieves a high diagnostic success rate.
  • Neuronavigation significantly enhances the accuracy and safety of intracranial biopsies.