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Published on: October 30, 2013
Gastric MALT lymphoma treated with primary radiotherapy in the setting of autoimmune disease
Chelsea C Pinnix1, Valerie Reed, Bouthaina Dabaja
1Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. CCPinnix@mdanderson.org
Abstract:
Autoimmune and microbial-induced immune reactions are associated with lymphomagenesis, particularly of extranodal marginal zone B-cell lymphomas. This report presents a case of Helicobacter pylori-negative gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in the setting of Sjögren syndrome and Hashimoto thyroiditis treated with primary involved-field radiotherapy. This report describes etiologic data, diagnostic and treatment considerations, and sophisticated radiation therapy techniques aimed at reducing long-term toxicity in this indolent disease.

