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Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

6.3K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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No description available
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Metastasis02:30

Metastasis

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Metastasis02:30

Metastasis

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No description available
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
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Related Experiment Video

Updated: Mar 11, 2026

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors
07:01

Obtaining Cancer Stem Cell Spheres from Gynecological and Breast Cancer Tumors

Published on: March 1, 2020

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Cancer stem cells and metastasis.

Katia Sampieri1, Riccardo Fodde

  • 1Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands.

Seminars in Cancer Biology
|July 10, 2012
PubMed
Summary

Cancer stem cells (CSCs) drive tumor metastasis and resistance to therapy. Research suggests targeting these cells may offer new treatment strategies for advanced cancers.

Area of Science:

  • Oncology
  • Cancer Biology
  • Stem Cell Research

Background:

  • Cancer stem cells (CSCs) are a distinct tumor cell subpopulation.
  • CSCs possess self-renewal and differentiation capabilities.
  • They exhibit inherent resistance to chemotherapy and radiotherapy.

Purpose of the Study:

  • To review the current literature on the relationship between CSCs and metastasis.
  • To explore the role of CSCs in tumor dissemination and recurrence.

Main Methods:

  • Literature review of studies on cancer cell lines and patient-derived materials.
  • Analysis of pre-clinical evidence for novel therapies targeting CSCs.

Main Results:

  • CSCs demonstrate characteristics relevant to metastasis, including motility and invasiveness.

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  • Preliminary data suggest CSCs play a critical role in tumor cell dissemination.
  • Evidence indicates novel therapies targeting disseminated CSCs show pre-clinical efficacy.

    • Conclusions:

    • CSCs are implicated in cancer metastasis and pose challenges for complete disease eradication.
    • Further research is needed to confirm CSCs as the origin of distant recurrences.
    • Targeting CSCs represents a promising therapeutic avenue for cancer treatment.