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Updated: May 20, 2026

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Can we decrease the acute proctitis in prostate cancer patients using hyaluronic acid during radiation therapy: a

A Stefanelli1, G Pascale, E Rainieri

  • 1Department of Oncology Radiotherapy, Arcispedale S'Anna Universitary Hospital, Ferrara, Italy.

European Review for Medical and Pharmacological Sciences
|July 11, 2012
PubMed
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Hyaluronic acid suppositories may help reduce acute radiation proctitis symptoms in prostate cancer patients undergoing radiotherapy. This treatment showed a delay in the onset of rectal toxicity, suggesting a beneficial role.

Area of Science:

  • Oncology
  • Radiation Oncology
  • Gastroenterology

Background:

  • Prostate cancer (PC) patients undergoing radiotherapy often experience acute radiation proctitis.
  • Effective symptom management for radiation-induced rectal toxicity is crucial.

Purpose of the Study:

  • To evaluate the efficacy of hyaluronic acid (HA) rectal suppositories in mitigating acute radiation proctitis symptoms.
  • To assess the impact of HA on the incidence and timing of rectal toxicity in PC patients.

Main Methods:

  • A prospective study involving 50 prostate cancer patients using daily HA suppositories before radiotherapy.
  • An historical control group was utilized for comparison.
  • Acute rectal toxicity was assessed weekly using RTOG criteria, with time to toxicity as the primary endpoint.

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Main Results:

  • Hyaluronic acid (HA) treatment demonstrated a trend towards reduced overall acute proctitis rates (32% vs. 45% in controls).
  • A statistically significant delay in the onset of acute rectal toxicity was observed in the HA group (p=0.04).
  • Good compliance was reported for the HA suppositories.

Conclusions:

  • Hyaluronic acid suppositories show potential in reducing acute radiation proctitis in prostate cancer patients receiving radiotherapy.
  • Further clinical trials are warranted to confirm these promising findings and establish HA as a standard supportive care option.