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Updated: May 1, 2026

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
Published on: February 24, 2015
Palladium-catalyzed borylation of primary alkyl bromides
Amruta Joshi-Pangu1, Xinghua Ma, Mohamed Diane
1Department of Chemistry, The City College of New York, 160 Convent Avenue, New York, New York 10031, USA.
Abstract:
A mild Pd-catalyzed process for the borylation of alkyl bromides has been developed using bis(pinacolato)diboron as a boron source. This process accommodates the use of a wide range of functional groups on the alkyl bromide substrate. Primary bromides react with complete selectivity in the presence of a secondary bromide. The generality of this approach is demonstrated by its extension to the use of alkyl iodides and alkyl tosylates, as well as borylation reactions employing bis(neopentyl glycolato)diboron as the boron source.
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