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Related Concept Videos

Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized by phagocytes.

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Related Experiment Video

Updated: May 20, 2026

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
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Published on: July 5, 2017

Flavonol-containing phosphorylated pullulan may attenuate pulp inflammation.

J Yonehiro1, Y Yoshida, A Yamashita

  • 1Department of Dental Science for Health Promotion, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan.

International Endodontic Journal
|July 11, 2012
PubMed
Summary
This summary is machine-generated.

Researchers explored luteolin, an anti-inflammatory agent, encapsulated in phosphorylated pullulan for dental pulp capping. This combination effectively reduced inflammation in pulpitis models, showing potential for new dental treatments.

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Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research
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Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research

Published on: October 27, 2023

Related Experiment Videos

Last Updated: May 20, 2026

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
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Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research
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Establishment of a Murine Pulp Exposure Model with a Novel Mouth-Gag for Pulpitis Research

Published on: October 27, 2023

Area of Science:

  • Dental Materials Science
  • Immunology
  • Biomaterials Engineering

Background:

  • Dental pulp inflammation is a significant clinical challenge.
  • Current pulp-capping materials have limitations in managing inflammatory responses.
  • Developing novel materials with anti-inflammatory properties is crucial for effective pulp regeneration.

Purpose of the Study:

  • To identify reagents that minimize inflammatory responses in pulpitis models.
  • To evaluate phosphorylated pullulan as a carrier for anti-inflammatory agents.
  • To develop new pulp-capping materials for dental applications.

Main Methods:

  • Utilized transwell co-culturing systems to model pulpitis.
  • Assessed inflammatory responses by measuring cytokine production.
  • Tested luteolin and quercetin as anti-inflammatory reagents, with phosphorylated pullulan as a carrier for luteolin.

Main Results:

  • Luteolin significantly reduced inflammatory cytokine production in co-cultures.
  • Phosphorylated pullulan successfully encapsulated luteolin.
  • Luteolin released from phosphorylated pullulan demonstrated efficacy in reducing cytokine levels.

Conclusions:

  • The combination of phosphorylated pullulan and luteolin shows promise for treating dental pulp inflammation.
  • This approach could lead to advanced pulp-capping materials.
  • Further research is warranted to explore clinical applications.