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Updated: May 20, 2026

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
Published on: January 7, 2014
Gene-environment interactions in Parkinson's disease: specific evidence in humans and mammalian models
Jason R Cannon1, J Timothy Greenamyre
1School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA. cannonjr@purdue.edu
Abstract:
Interactions between genetic factors and environmental exposures are thought to be major contributors to the etiology of Parkinson's disease. While such interactions are poorly defined and incompletely understood, recent epidemiological studies have identified specific interactions of potential importance to human PD. In this review, the most current data on gene-environment interactions in PD from human studies are critically discussed. Animal models have also highlighted the importance of genetic susceptibility to toxicant exposure and data of potential relevance to human PD are discussed. Goals and needs for the future of the field are proposed.
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