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Serotonin transport and synthesis systems during early development of invertebrates: functional analysis on a bivalve
E G Ivashkin1, Marina Yu Khabarova, Elena E Voronezhskaya
1Department of Comparative Physiology, Institute of Developmental Biology RAS, Moscow, Russia. veliger@yandex.ru
Abstract:
Serotonin (5.HT) is known to be functionally active during early development in both vertebrates and invertebrates. However, the presence of 5-HT and its synthesis and transport system has not yet been demonstrated in bivalve early development. The presence of 5-HT was immunochemically demonstrated at the cleavage stage of bivalve Mytilus trossulus. 5-HT level dramatically increased within all embryonic cells after incubation with 5-HTP but not after incubation with tryptophan and 5-HT. The first 5-HT uptake by specific transporter was detected at 13 hpf blastula stage only and it was restricted to one distinct cell.
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